15183-37-6

15183-37-6 structure

Name: Estetrol
Chemical Name: (8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol
CAS Number: 15183-37-6
Molecular Formula: C₁₈H₂₄O₄
Molecular Weight: 304.38100
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-03-20 07:04:11
Modify Date: 2026-07-01 18:07:41
Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast[1][2].

Name	(8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol
Synonyms	15-ALPHA-HYDROXYESTRIOL 3,15a,16a,17-Tetrahydroxyestra-1,3,5-triene (8R,9S,13S,14S,15R,16R,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,15,16,17-tetraol 15α-Hydroxyestriol 15a-Hydroxyestriol 15\|A-Hydroxyestriol Estra-1,3,5-triene-3,15,16,17-tetrol, (15α,16α,17β) Estetrol, 10 mM in DMSO 1, 3, 5-ESTRATRIEN-3, 15α, 16α, 17β-TETROL HDNB1 E 4 ESTETROL Estra-1,3,5-triene-3,15,16,17-tetrol,(15a,16a,17b) (15α,16α,17β)-Estra-1,3,5-triene-3,15,16,17-tetrol Estra-1,3,5-triene-3,15α,16α,17β-tetrol UBE4A UFD2A Estetrol (E4) M133315 UBOX3 Donesta KIAA0684 1,3,5-ESTRATRIEN-3,15-ALPHA, 16-ALPHA, 17-BETA-TETROL KIAA0126 3,15α,16α,17β-Tetrahydroxyestra-1,3,5-triene (15a,16a,17)-Estra-1,3,5-triene-3,15,16,17-tetrol Estra-1,3,5-triene-3,15a,16a,17-tetrol

Description	Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cardiovascular Disease
Target	Estrogen receptor[1]
References	[1]. Valéra MC, et al. Effect of estetrol, a selective nuclear estrogen receptor modulator, in mouse models of arterial and venous thrombosis. Mol Cell Endocrinol. 2018 Dec 5;477:132-139. [2]. Montt-Guevara MM, et al. Estetrol Modulates Endothelial Nitric Oxide Synthesis in Human Endothelial Cells. Front Endocrinol (Lausanne). 2015 Jul 22;6:111.

RIDADR	NONH for all modes of transport

16127-99-4

15183-37-6

53-16-7

15183-37-6

Literature: EP2383279 A1, ;

138743-03-0

15183-37-6

Literature: EP2383279 A1, ;

858-98-0

15183-37-6

Literature: EP2383279 A1, ;

213819-19-3

15183-37-6

Literature: EP2383279 A1, ;

16127-98-3

15183-37-6

Literature: Steroids, , vol. 60, # 3 p. 277 - 284