Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Phenanthrenecarboxylicacid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S,4aS,10aR)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: podocarpic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

5947-49-9

5947-49-9 structure

5947-49-9 structure

Name: Podocarpic acid
Chemical Name: podocarpic acid
CAS Number: 5947-49-9
Molecular Formula: C₁₇H₂₂O₃
Molecular Weight: 274.35500
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2018-08-09 18:25:34
Modify Date: 2024-01-06 22:12:57
Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

Name	podocarpic acid
Synonyms	1 4A-DIMETHYL-6-HYDROXY-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID MFCD00074825 PODOCARPIC ACID Einecs 227-706-3 12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID

Description	Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides
In Vitro	Podocarpic acid anhydride acts as a 1 nM agonist of LXRalpha and beta receptors. It shows over 8-10-fold better activator of LXR receptors compared to one of the natural ligands, 22-(R)-hydroxy cholesterol, in HEK-293 cells[2].
In Vivo	Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca2+ flux, which is significantly reduces when the Ca2+-impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels[1].
References	[1]. Baraka HN. Microbial transformation of podocarpic acid and evaluation of transformation products for antioxidant activity. Planta Med. 2010 May;76(8):815-7. [2]. Singh S, et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2824-8.

Melting Point	193-196 â„ƒ(lit.)
Molecular Formula	C₁₇H₂₂O₃
Molecular Weight	274.35500
Exact Mass	274.15700
PSA	57.53000
LogP	3.48710
Storage condition	-20°C

HS Code	2916209090

Precursor 3
1231-74-9 125446-62-0 123427-81-6
DownStream 4
832-69-9 111589-13-0 81801-25-4 40061-88-9

HS Code	2916209090
Summary	2916209090 other cyclanic, cyclenic or cyclotherpenic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%