Top Suppliers:I want be here



173903-47-4

173903-47-4 structure
173903-47-4 structure
  • Name: Tizoxanide
  • Chemical Name: 2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
  • CAS Number: 173903-47-4
  • Molecular Formula: C10H7N3O4S
  • Molecular Weight: 265.245
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-12-01 09:56:16
  • Modify Date: 2025-08-27 09:51:47
  • Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses.IC50 value: Target: Antiviral agentin vitro: Tizoxanide inhibited virus replication of all CIVs with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively [2]. Nitazoxanide and its primary metabolite, tizoxanide, inhibit hepatitis C virus (HCV) replication in HCV replicon systems. Interestingly, serial passage in nitazoxanide or tizoxanide resulted in increased sensitivity to alpha interferon 2b: EC(50)s and EC(90)s were reduced three- and eightfold, respectively [3].

Name 2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
Synonyms 2-hydroxy-N-(5-nitrothiazol-2-yl)benzamide
Tizoxanide
Desacetylnitazoxanide
Benzamide, 2-hydroxy-N-(5-nitro-2-thiazolyl)-
Desacetyl-nitazoxanide
NTZdes
2-Hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide
Description Tizoxanide is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses.IC50 value: Target: Antiviral agentin vitro: Tizoxanide inhibited virus replication of all CIVs with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively [2]. Nitazoxanide and its primary metabolite, tizoxanide, inhibit hepatitis C virus (HCV) replication in HCV replicon systems. Interestingly, serial passage in nitazoxanide or tizoxanide resulted in increased sensitivity to alpha interferon 2b: EC(50)s and EC(90)s were reduced three- and eightfold, respectively [3].
Related Catalog
References

[1]. Korba BE, et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res. 2008 Jan;77(1):56-63.

[2]. Ashton LV, et al. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Vet Med Int. 2010 Aug 12;2010. pii: 891010.

[3]. Korba BE, et al. Potential for hepatitis C virus resistance to nitazoxanide or tizoxanide. Antimicrob Agents Chemother. 2008 Nov;52(11):4069-71.

Density 1.6±0.1 g/cm3
Melting Point 279-281ºC(dec)
Molecular Formula C10H7N3O4S
Molecular Weight 265.245
Exact Mass 265.015717
PSA 136.28000
LogP 2.91
Index of Refraction 1.750
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.