102978-40-5

102978-40-5 structure
102978-40-5 structure
  • Name: (±)- 1H-Pyrano[3,4-f]indolizine-3,6,10(4H)-trione, 4-ethyl-7,8-dihydro-4-hydroxy
  • Chemical Name: 4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4 H)-trione
  • CAS Number: 102978-40-5
  • Molecular Formula: C13H13NO5
  • Molecular Weight: 263.25
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
  • Create Date: 2018-06-13 13:45:21
  • Modify Date: 2025-08-25 18:02:09
  • (rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer[1][2].

Name 4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4 H)-trione
Synonyms 4-ethyl-6-oxo-1,4,7,8-tetrahydro-4-hydroxy-pyrano [3,4-f]indolizine-3,10(6H)-dione
4-ethyl-6-methyl-DBT
4-ethyl-1,4,7,8-tetrahydro-4-hydroxypyrano[3,4-f]indolizine-3,6,10-trione
4-Ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
7,8-dihydro-4-ethyl-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
Description (rac)-Exatecan Intermediate 1 is an isomer of Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631), a camptothecin-based anticancer agent. Exatecan inhibits tumor growth by interfering with the proliferation and division of tumor cells by interacting with DNA. Exatecan is primarily used in research into a variety of cancers including ovarian, lung and breast cancer[1][2].
Related Catalog
References

[1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973.  

[2]. Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31.

Molecular Formula C13H13NO5
Molecular Weight 263.25
Exact Mass 263.07900
PSA 85.60000
LogP 0.08910
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