106410-13-3

106410-13-3 structure

Name: NSC 140873
Chemical Name: 2-amino-N-[4-chloro-2-(1H-pyrrole-2-carbonyl)phenyl]acetamide
CAS Number: 106410-13-3
Molecular Formula: C₁₃H₁₂ClN₃O₂
Molecular Weight: 277.71
Create Date: 2017-02-08 14:40:53
Modify Date: 2024-01-07 12:40:46
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2].

Name	2-amino-N-[4-chloro-2-(1H-pyrrole-2-carbonyl)phenyl]acetamide
Synonyms	2-glycine amide-5-chlorophenyl 2-pyrryl ketone GCPK

Description	NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	NSC 140873 (1 至 100 μM，5-6 天) 降低斑马鱼胚胎中的确定性造血功能[2]。 NSC 140873 对高表达 RUNX1 的细胞具有抗增殖活性[2]。
References	[1]. Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1. [2]. Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7.