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106410-13-3

106410-13-3 structure
106410-13-3 structure
  • Name: NSC 140873
  • Chemical Name: 2-amino-N-[4-chloro-2-(1H-pyrrole-2-carbonyl)phenyl]acetamide
  • CAS Number: 106410-13-3
  • Molecular Formula: C13H12ClN3O2
  • Molecular Weight: 277.71
  • Create Date: 2017-02-08 14:40:53
  • Modify Date: 2025-08-25 17:46:26
  • NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2].

Name 2-amino-N-[4-chloro-2-(1H-pyrrole-2-carbonyl)phenyl]acetamide
Synonyms 2-glycine amide-5-chlorophenyl 2-pyrryl ketone
GCPK
Description NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335)[1][2].
Related Catalog
In Vitro NSC 140873 (1 至 100 μM,5-6 天) 降低斑马鱼胚胎中的确定性造血功能[2]。 NSC 140873 对高表达 RUNX1 的细胞具有抗增殖活性[2]。
References

[1]. Pu Liu, et al. Methods for treating leukemia and disorders mediated by cbfβ and runx1 proteins. Patent. WO2012125787A1.

[2]. Cunningham L, et al. Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14592-7.  

Molecular Formula C13H12ClN3O2
Molecular Weight 277.71
Exact Mass 277.06200
PSA 91.47000
LogP 3.14610
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