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5122-36-1

5122-36-1 structure
5122-36-1 structure
  • Name: FAPy-adenine
  • Chemical Name: 4,6-diamino-5-formamidopyrimidine
  • CAS Number: 5122-36-1
  • Molecular Formula: C5H7N5O
  • Molecular Weight: 281.266
  • Catalog: Research Areas Cancer
  • Create Date: 2018-12-29 12:55:37
  • Modify Date: 2024-01-11 18:42:40
  • FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].
Name 4,6-diamino-5-formamidopyrimidine
Synonyms Fapyade
FAPy
3H-Pyrazol-3-one, 2,4-dihydro-2-(4-nitrophenyl)-5-phenyl-
N-(4,6-diaminopyrimidin-5-yl)formamide
4,6-Diamino-5-formamidopyrimidine
4,6-Diamino-5-N-formamidopyrimidine
2-(4-Nitrophenyl)-5-phenyl-2,4-dihydro-3H-pyrazol-3-one
4,6-Diamino-5-pyrimidinylformamide
Description FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine[1].
In Vivo The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease[1].
References

[1]. Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease.

[2]. Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45.

[3]. Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7.
Density 1.4±0.1 g/cm3
Boiling Point 464.7±47.0 °C at 760 mmHg
Molecular Formula C5H7N5O
Molecular Weight 281.266
Flash Point 234.8±29.3 °C
Exact Mass 281.080048
PSA 106.92000
LogP 1.92
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.674
HS Code 2933599090
64-18-6 structure

64-18-6

49721-45-1 structure

49721-45-1

~%

5122-36-1 structure

5122-36-1

Literature: Abrams; Clark Journal of the American Chemical Society, 1951 , vol. 73, p. 4609 Full Text View citing articles Show Details Cavalieri; Brown Journal of the American Chemical Society, 1949 , vol. 71, p. 2246
64-18-6 structure

64-18-6

118-70-7 structure

118-70-7

~%

5122-36-1 structure

5122-36-1

Literature: Cavalieri; Tinker; Bendich Journal of the American Chemical Society, 1949 , vol. 71, p. 535
66224-66-6 structure

66224-66-6

~%

5122-36-1 structure

5122-36-1

21149-26-8 structure

21149-26-8

Literature: Vieira; Steenken Journal of the American Chemical Society, 1990 , vol. 112, # 19 p. 6986 - 6994
HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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