104375-88-4

104375-88-4 structure

Name: 5'-DMT-5-I-2'-dU
Chemical Name: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione
CAS Number: 104375-88-4
Molecular Formula: C₃₀H₂₉IN₂O₇
Molecular Weight: 656.46
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2019-07-05 07:34:57
Modify Date: 2024-01-08 15:04:57
5’-O-DMTr-5-iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione
Synonyms	5'-O-DMTr-IUdR 5-iodo-5'-DMT-2'-deoxyuridine 2'-Deoxy-5'-O-DMT-5-iodouridine 5'-DMT-5-I-2'-dU

Description	5’-O-DMTr-5-iodo-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.