123039-93-0

123039-93-0 structure

Name: Dihydrexidine
Chemical Name: 5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
CAS Number: 123039-93-0
Molecular Formula: C₁₇H₁₇NO₂
Molecular Weight: 303.78300
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-06-05 08:00:00
Modify Date: 2024-01-02 15:46:05
Dihydrexidine (DAR-100) is a high potent, selective and full efficacy D1 dopamine receptor agonist with an IC50 of 10 nM, and displays some affinity for the D2 receptor. Dihydrexidine (DAR-100) exhibits potent antiparkinsonian activity[1][2][3].

Name	5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
Synonyms	dihydrexidine dar0100a

Description	Dihydrexidine (DAR-100) is a high potent, selective and full efficacy D1 dopamine receptor agonist with an IC50 of 10 nM, and displays some affinity for the D2 receptor. Dihydrexidine (DAR-100) exhibits potent antiparkinsonian activity[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	IC50: 10 nM (D1 dopamine receptor)[1]
References	[1]. Lovenberg TW, et al. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. Eur J Pharmacol. 1989 Jul 4;166(1):111-3. [2]. Mottola DM, et al. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther. 1992 Jul;262(1):383-93. [3]. Salmi P,et al. Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev. 2004 Fall;10(3):230-42.