76135-31-4

76135-31-4 structure

Name: 8-Hydroxy-DPAT hydrobromide
Chemical Name: 8-Hydroxy-DPAT hydrobromide,(±)-7-Hydroxy-2-dipropylaminotetralinhydrobromide
CAS Number: 76135-31-4
Molecular Formula: C₁₆H₂₆BrNO
Molecular Weight: 328.28800
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-12-28 14:33:46
Modify Date: 2024-01-08 16:34:03
8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].

Name	8-Hydroxy-DPAT hydrobromide,(±)-7-Hydroxy-2-dipropylaminotetralinhydrobromide
Synonyms	8-OH-DPAT HRr rac-8-Hydroxy-2-dipropylaMinotetralin HydrobroMide Serotonin agonist DPAT 8-OH-DPAT hydrobromide 8-hydroxydipropyl-aminotetralin 8-OH-DPAT HBr

Description	8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1A Receptor:8.19 (pIC50)
In Vitro	8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) has no effect on 5-HT1B binding at concentrations lower than 100 nM[1].
In Vivo	8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide; 32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1].
References	[1]. D N Middlemiss, et al. 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT₁ recognition site. Eur J Pharmacol. 1983 May 20;90(1):151-3. [2]. Michael A Taffe, et al. Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge. Neuropsychopharmacology. 2002 Dec;27(6):993-1005.

HS Code	2922299090

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%