405518-55-0

405518-55-0 structure

Name: m-PEG9-CH2COOH
Chemical Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
CAS Number: 405518-55-0
Molecular Formula: C₂₁H₄₂O₁₂
Molecular Weight: 486.55100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-11-28 10:56:17
Modify Date: 2024-01-02 16:26:09
m-PEG9-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
Synonyms	2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-oic acid 3,6,9,12,15,18,21,24,27,30-DECAOXAHENTRIACONTANOIC ACID

Description	m-PEG9-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.