Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: thioproperazine
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316-81-4

316-81-4 structure

Name: Thioproperazine
Chemical Name: thioproperazine
CAS Number: 316-81-4
Molecular Formula: C₂₂H₃₀N₄O₂S₂
Molecular Weight: 446.62900
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-08-02 19:57:57
Modify Date: 2024-01-02 16:12:12
Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1].

Name	thioproperazine
Synonyms	2-Dimethylsulfamoyl-10-<3-(4-methyl-piperazin-1-yl)-propyl>-phenothiazin 10-[3-(4-methyl-piperazin-1-yl)-propyl]-10H-phenothiazine-2-sulfonic acid dimethylamide Majeptyl Megeptil Thioproperazine Sulfenazin N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide 10-<3-(4-Methyl-piperazin-1-yl)-propyl>-phenothiazin-2-sulfonsaeure-dimethylamid Cephalmin Thioperazine Mazeptyl Thioproperazin thiproperazine Vontil Tioproferazina

Description	Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
In Vivo	Thioproperazine (5 mg/kg; i.p.; single) increases accumulation of dopamine in rat striatum[1]. Animal Model: Male charles river rats (200-250 g)[1]. Dosage: 5 mg/kg Administration: Intraperitoneal injection; single. Result: Markedly decreased dopamine levels (26%), and accelerated synthesis and utilization of dopamine in the striatum (dopamine specific activity was enhanced 250%).

Density	1.237g/cm3
Boiling Point	612.2ºC at 760mmHg
Melting Point	140ºC
Molecular Formula	C₂₂H₃₀N₄O₂S₂
Molecular Weight	446.62900
Flash Point	324ºC
Exact Mass	446.18100
PSA	80.78000
LogP	4.19870
Index of Refraction	1.615

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP5400000

CHEMICAL NAME :: Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-

CAS REGISTRY NUMBER :: 316-81-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C22-H30-N4-O2-S2

MOLECULAR WEIGHT :: 446.68

WISWESSER LINE NOTATION :: T C666 BN ISJ ESWN1&1 B3- AT6N DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 200 mg/kg

SEX/DURATION :: female 1-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

REFERENCE :: CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(5),14,1975

HS Code	2935009090

5510-56-5

316-81-4

Literature: Pharmaceutical Chemistry Journal, , vol. 8, # 5 p. 286 - 290 Khimiko-Farmatsevticheskii Zhurnal, , vol. 8, # 5 p. 23 - 28

53106-13-1

316-81-4

Literature: Pharmaceutical Chemistry Journal, , vol. 8, # 5 p. 286 - 290 Khimiko-Farmatsevticheskii Zhurnal, , vol. 8, # 5 p. 23 - 28

53106-12-0

316-81-4

Literature: Pharmaceutical Chemistry Journal, , vol. 8, # 5 p. 286 - 290 Khimiko-Farmatsevticheskii Zhurnal, , vol. 8, # 5 p. 23 - 28

1217018-61-5

1090-78-4

316-81-4

Literature: Pharmaceutical Chemistry Journal, , vol. 8, # 5 p. 286 - 290 Khimiko-Farmatsevticheskii Zhurnal, , vol. 8, # 5 p. 23 - 28

Precursor 4
5510-56-5 53106-13-1 1217018-61-5 1090-78-4
DownStream 0

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%