1402-82-0

1402-82-0 structure

Name: Amphomycin
Chemical Name: Amphomycin
CAS Number: 1402-82-0
Molecular Formula: C₅₈H₉₁N₁₃O₂₀
Molecular Weight: 1290.42000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-04-20 08:00:00
Modify Date: 2024-01-02 15:43:41
Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci[1][2][3].

Name	Amphomycin

Description	Amphomycin is a lipopeptide antibiotic that inhibits peptidoglycan synthesis and blocks cell wall development. Amphomycin exhibits potent antibacterial activities against methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant S. pneumonia, and linezolid-quinupristin-dalfopristin-resistant enterococci[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Amphomycin (40 μ g/mL; 60 min) leads S. aureus to exhibit cell wall thinning and Park’s nucleotide accumulation[1]. Cell Viability Assay[1] Cell Line: S. aureus whole cells Concentration: 40 μ g/mL Incubation Time: 60 min Result: Resulted in the thinning of cell wall and the accumulation of Park’s nucleotide.
In Vivo	Amphomycin (50 mg/kg; p.o.; single) shows low oral availability and (5-10mg/kg; i.v.; single) exhibits a long half-life (5.2-8.0 h in mice and 4.6-7.1 h in rats)[2].

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(1),317,1980

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 30,9,1963

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,131,1967