Name | th287 |
---|---|
Synonyms |
6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N-methyl- 6-(2,3-Dichlorophenyl)-N-methyl-2,4-pyrimidinediamine |
Description | TH287 is a potent inhibitor of MTH1 (NUDT1) with an IC50 value of 0.8 nM, less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.IC50 value: 0.8 nM [1]Target: MTH1 inhibitorTH287 is considered a new target for cancer therapy. TH287 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family. TH287 has been shown to selectively kill a variety of cancer cell lines, but is rapidly metablized, so not as useful for in vivo studies. |
---|---|
Related Catalog | |
References |
Density | 1.4±0.1 g/cm3 |
---|---|
Boiling Point | 512.2±60.0 °C at 760 mmHg |
Molecular Formula | C11H10Cl2N4 |
Molecular Weight | 269.130 |
Flash Point | 263.5±32.9 °C |
Exact Mass | 268.028259 |
PSA | 37.81000 |
LogP | 3.48 |
Appearance | white solid |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.681 |
Storage condition | 2-8℃ |