22733-60-4
22733-60-4 structure
- Name: NSC 135048
- Chemical Name: Siccanin
- CAS Number: 22733-60-4
- Molecular Formula: C22H30O3
- Molecular Weight: 342.47
- Catalog: API Synthetic anti-infective drugs Antifungal drugs
- Create Date: 2018-02-21 08:00:00
- Modify Date: 2024-01-07 02:05:39
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Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi[1].
| Name | Siccanin |
|---|---|
| Synonyms |
Sicanina
Siccanine |
| Description | Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi[1]. |
|---|---|
| Related Catalog | |
| Target |
Succinate Dehydrogenase Inhibitor |
| In Vitro | Siccanin (10 μg/mL) 具有物种选择性，Siccanin 抑制铜绿假单胞菌和恶臭假单胞菌的细菌 SDH，但不抑制大肠杆菌和谷氨酸棒杆菌的 SDH；Siccanin 抑制啮齿动物 SDH 但不抑制猪 SDH[1]。 具体而言，Siccanin 抑制铜绿假单胞菌（残留活性 13%）和恶臭假单胞菌（>1%）膜以及小鼠（>7%）和大鼠（19%）肝线粒体的 SDH，但不抑制大肠杆菌的 SDH (77%) 和谷氨酸棒杆菌 (97%) 膜和猪心脏线粒体 (106%)[1]。 Siccanin (3 μg/mL) 竞争性抑制须癣毛癣菌的生长 (IC50=0.3 μg/mL)[1]。 |
| References |
| Density | 1.18g/cm3 |
|---|---|
| Boiling Point | 427.8ºC at 760mmHg |
| Melting Point | 139-140° |
| Molecular Formula | C22H30O3 |
| Molecular Weight | 342.47 |
| Flash Point | 212.5ºC |
| Exact Mass | 342.21900 |
| PSA | 38.69000 |
| LogP | 5.14570 |
| Vapour Pressure | 6.41E-08mmHg at 25°C |
| Index of Refraction | 1.593 |