61116-33-4
61116-33-4 structure
- Name: AM 1042
- Chemical Name: asukamycin
- CAS Number: 61116-33-4
- Molecular Formula: C31H34N2O7
- Molecular Weight: 546.61100
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2016-12-12 22:55:56
- Modify Date: 2024-02-06 11:12:13
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Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an Antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines[1][2].
| Name | asukamycin |
|---|
| Description | Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an Antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Asukamycin (1-50 μM; 24 h) 以浓度依赖的方式降低五种不同人类细胞系的活力，其 IC50 值为 1-5 μM[1]。 Asukamycin (50 μM; 24 and 72 h; THP-1 细胞) 导致细胞内 caspase 8 和 caspase 3 活性显著增加[1]。 Asukamycin (0-100 mcg/mL; 细菌, 18 h; 真菌, 72 h) 具有抗菌活性。Asukamycin 在 0.78-12.5 mcg/mL 的浓度范围内抑制革兰氏阳性菌的生长，在 25 mcg/mL 的浓度范围内抑制 Trichophyton mentagrophytes 的生长。 Cell Viability Assay[1] Cell Line: Human myeloid THP-1, HL-60, U-118 MG, U-87 MG and U-937 cells Concentration: 1-50 μM Incubation Time: 24 hours Result: Reduced viability of five different cell lines in a concentration-dependent manner. |
| In Vivo | Asukamycin (0-450 mg/kg; i.p.; 小鼠) 体内毒性低。Asukamycin 具有急性毒性，腹腔注射时 LD50 值为 48.5 mg/kg[2]。 Animal Model: Mice[2] Dosage: 0-450 mg/kg Administration: Intraperitoneal injection Result: Had no effect on mice when administered by 450 mg/kg and the acute toxicity (LD50) was 48.5 mg/kg by intraperitoneal injection. |
| References |
| Molecular Formula | C31H34N2O7 |
|---|---|
| Molecular Weight | 546.61100 |
| Exact Mass | 546.23700 |
| PSA | 145.33000 |
| LogP | 4.01570 |