120287-85-6

120287-85-6 structure

Name: Antide acetate salt
Chemical Name: cetrorelix
CAS Number: 120287-85-6
Molecular Formula: C₇₀H₉₂ClN₁₇O₁₄
Molecular Weight: 1431.038
Catalog: API Hormone and endocrine-regulating drugs Gonadotropin
Create Date: 2018-08-30 21:57:20
Modify Date: 2024-01-02 18:06:42
Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice[1][2].

Name	cetrorelix
Synonyms	N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide CETRORELIX ACETATE(CETROTIDE) N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2 Cetrorelixum [inn-latin] (2S)-N-[(2R)-1-Amino-1-oxopropan-2-yl]-1-[(2S,5S,8R,11S,14S,17R,20R,23R)-2-(3-carbamimidamidopropyl)-8-[3-(carbamoylamino)propyl]-20-(4-chlorobenzyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-5-isobutyl-23-(2-naphthylmethyl)-4,7,10,13,16,19,22,25-octaoxo-17-(pyridin-3-ylmethyl)-3,6,9,12,15,18,21,24-octaazahexacosan-1-oyl]pyrrolidine-2-carboxamide (non-preferred name) Ac-DNal-DpCl-Phe-DPal-Ser-Tyr-DCit-Leu-Arg-Pro-D-Ala-NH2 N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide Cetrorelixacetate Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH2 AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH Cetrorelixum cetrorelixum [INN_la] CETRORELIX ACID D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl- Unii-oon1hfz4ba CETRIZINEDIHYDROCHLORIDE Cetrorelix acetate N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-L-tyrosyl-N-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide AC-D-2-NAL-4-CHLORO-D-PHE-B-(3-PYRIDYL)-D-ALA-SER-TYR-D-CIT-LEU-ARG-PRO-D-ALA-NH2 Cetrorelix

Description	Cetrorelix is a potent gonadotrophin-releasing hormone (GnRH) antagonist. Cetrorelix inhibits the endogenous luteinizing hormone surge during ovarian stimulation. Cetrorelix reduces cyclophosphamide induced ovarian follicular destruction in mice[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Endocrinology
References	[1]. Diedrich K, et al. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod. 1994 May;9(5):788-91. [2]. Meirow D, et al. The GnRH antagonist cetrorelix reduces cyclophosphamide-induced ovarian follicular destruction in mice. Hum Reprod. 2004 Jun;19(6):1294-9.

Density	1.4±0.1 g/cm3
Molecular Formula	C₇₀H₉₂ClN₁₇O₁₄
Molecular Weight	1431.038
Exact Mass	1429.669800
PSA	495.67000
LogP	2.69
Index of Refraction	1.668
Storage condition	2-8°C

15761-39-4

13139-15-6

3744-87-4

13836-37-8

Detail

Literature: Journal of medicinal chemistry, , vol. 36, # 7 p. 928 - 933

Precursor 4
15761-39-4 13139-15-6 3744-87-4 13836-37-8
DownStream 0

120287-85-6	625092-10-6
14636-12-5	664334-36-5
5453-04-3	55508-42-4
188627-80-7	138068-37-8
96087-38-6	70904-56-2