56282-36-1

56282-36-1 structure

Name: Thiol-C2-PEG2-OH
Chemical Name: 3,6-Dioxa-8-mercaptooctan-1-ol
CAS Number: 56282-36-1
Molecular Formula: C₆H₁₄O₃S
Molecular Weight: 166.23900
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-12-22 20:24:08
Modify Date: 2024-01-05 20:35:06
Thiol-C2-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	3,6-Dioxa-8-mercaptooctan-1-ol
Synonyms	2-[2-(2-sulfanylethoxy)ethoxy]ethanol

Description	Thiol-C2-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.094g/cm3
Boiling Point	270.3ºC at 760 mmHg
Molecular Formula	C₆H₁₄O₃S
Molecular Weight	166.23900
Flash Point	117.3ºC
Exact Mass	166.06600
PSA	77.49000
Index of Refraction	1.475

5197-62-6

~80%

56282-36-1

Literature: Boden, Neville; Bushby, Richard J.; Liu, Quanying; Evans, Stephen D.; Toby; Jenkins; Knowles, Peter F.; Miles, Robert E. Tetrahedron, 1998 , vol. 54, # 38 p. 11537 - 11548

62573-16-4

~84%

56282-36-1

Literature: Asseline; Bonfils; Kurfurst; Chassignol; Roig; Thuong Tetrahedron, 1992 , vol. 48, # 7 p. 1233 - 1254

5197-62-6

728033-14-5

56282-36-1

Literature: Hutchison, James E.; Woehrle, Gerd H.; Warner, Marvin G.; Brown, Leif O. Patent: US2009/99044 A1, 2009 ;

153870-20-3

56282-36-1

Literature: Conte, Mauro Lo; Robb, Maxwell J.; Hed, Yvonne; Marra, Alberto; Malkoch, Michael; Hawker, Craig J.; Dondoni, Alessandro Journal of Polymer Science, Part A: Polymer Chemistry, 2011 , vol. 49, # 20 p. 4468 - 4475

5197-62-6

17356-08-0

56282-36-1

Literature: Charvet, Nicolas; Reiss, Peter; Roget, Andre; Dapuis, Alain; Gruenwald, Didier; Carayon, Sophie; Chandezon, Frederic; Livache, Thierry Journal of Materials Chemistry, 2004 , vol. 14, # 17 p. 2638 - 2642

Precursor 2
5197-62-6 62573-16-4
DownStream 1
97463-42-8

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