CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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AM1050000
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CHEMICAL NAME :
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Acetonitrile, ((alpha-methylphenethyl)amino)phenyl-
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CAS REGISTRY NUMBER :
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17590-01-1
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LAST UPDATED :
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199706
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C17-H18-N2
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MOLECULAR WEIGHT :
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250.37
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WISWESSER LINE NOTATION :
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NCYR&MY1&1R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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37600 ug/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation
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REFERENCE :
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TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 24,823,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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58800 ug/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation
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REFERENCE :
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TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 24,823,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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95100 ug/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation
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REFERENCE :
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TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 24,823,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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182 mg/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation
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REFERENCE :
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TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 24,823,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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491 mg/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation
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REFERENCE :
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TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 24,823,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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58 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,335,1972
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