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152529-79-8

152529-79-8 structure
152529-79-8 structure
  • Name: PSB 1115
  • Chemical Name: 4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid
  • CAS Number: 152529-79-8
  • Molecular Formula: C14H14N4O5S
  • Molecular Weight: 350.35000
  • Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
  • Create Date: 2017-05-19 15:33:43
  • Modify Date: 2025-08-26 08:28:04
  • PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1].
Name 4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid
Synonyms Tocris-2009
Description PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1].
Related Catalog
Target

A2BR

In Vitro PSB-1115 (100 μM) 在回肠/空肠段中抑制 TNBS (10 mM) 诱导的 ACh 收缩抑制现象[1]。
In Vivo PSB-1115 (0.5 mg/kg; i.p.; single dose, 20 min before the inhalation) antagonizes the inhibitory effect of non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice[2].
References

[1]. Michael S, et al. Adenosine A(2A) agonist and A(2B) antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation. Purinergic Signal. 2010 Mar;6(1):117-24.  

Molecular Formula C14H14N4O5S
Molecular Weight 350.35000
Exact Mass 350.06800
PSA 146.29000
LogP 1.81740
Storage condition -20°C
152529-72-1 structure

152529-72-1

~85%

152529-79-8 structure

152529-79-8

Literature: Mueller, Christa E.; Shi, Dan; Manning, Malcolm; Daly, John W. Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3341 - 3349
5399-63-3 structure

5399-63-3

~%

152529-79-8 structure

152529-79-8

Literature: Mueller, Christa E.; Shi, Dan; Manning, Malcolm; Daly, John W. Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3341 - 3349
142665-13-2 structure

142665-13-2

~%

152529-79-8 structure

152529-79-8

Literature: Mueller, Christa E.; Shi, Dan; Manning, Malcolm; Daly, John W. Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3341 - 3349
666716-03-6 structure

666716-03-6

~%

152529-79-8 structure

152529-79-8

Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043
10130-89-9 structure

10130-89-9

~%

152529-79-8 structure

152529-79-8

Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043
666715-86-2 structure

666715-86-2

~%

152529-79-8 structure

152529-79-8

Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043
636-78-2 structure

636-78-2

~%

152529-79-8 structure

152529-79-8

Literature: Hayallah, Alaa M.; Sandoval-Ramirez, Jesus; Reith, Ulrike; Schobert, Ulrike; Preiss, Birgit; Schumacher, Britta; Daly, John W.; Mueller, Christa E. Journal of Medicinal Chemistry, 2002 , vol. 45, # 7 p. 1500 - 1510
666715-95-3 structure

666715-95-3

~%

152529-79-8 structure

152529-79-8

Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043
666716-03-6 structure

666716-03-6

~%

554-84-7 structure

554-84-7

152529-79-8 structure

152529-79-8

Literature: Yan, Luo; Mueller, Christa E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1031 - 1043
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