157283-66-4

157283-66-4 structure

Name: Cloprostenol isopropyl ester
Chemical Name: (+)-Cloprostenol isopropyl ester
CAS Number: 157283-66-4
Molecular Formula: C₂₅H₃₅ClO₆
Molecular Weight: 466.99500
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2017-05-28 15:49:00
Modify Date: 2025-08-23 22:20:58
Cloprostenol isopropyl ester, a prostaglandin F2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a Ki value of 28 nM[1][2].

Name	(+)-Cloprostenol isopropyl ester
Synonyms	Cloprostenol isopropyl ester CPG 6112-95

Description	Cloprostenol isopropyl ester, a prostaglandin F2α analogs, is the intermediate of (+)-Cloprostenol (HY-107381). Cloprostenol isopropyl ester is a FP receptor agonist with a Ki value of 28 nM[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
In Vivo	Cloprostenol isopropyl ester (25 μg/kg; i.p.; daily, for 4 weeks; male mice) induces changes in the evolution of the spermatogenesis and spermiogenesis[1]. Cloprostenol isopropyl ester (1 μg, 30 μL; injected into the eye; for 2, 4 and 6 h) causes pupil constriction in the cat. Cloprostenol isopropyl ester has an efficacious ocular hypotensive in the lasered monkey[2]. Animal Model: Male mice (50–80 days)[1] Dosage: 25 μg/kg Administration: Intraperitoneal injection; daily, for 4 weeks Result: Stimulated the androgen synthesis in a time-dependent manner.
References	[1]. Sava A, et, al. Electron microscopic aspects of the effects of certain prostaglandin analogs on mouse testes. Rom J Morphol Embryol. 2015;56(2 Suppl):771-5. [2]. Hellberg MR, et, al. Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S13-33.