859502-43-5

859502-43-5 structure

Name: GR 125487 sulfamate
Chemical Name: Sulfamic acid-(1-{2-[(methylsulfonyl)amino]ethyl}-4-piperidinyl )methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate (1:1)
CAS Number: 859502-43-5
Molecular Formula: C₁₉H₂₉FN₄O₈S₂
Molecular Weight: 524.58
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2016-09-19 04:57:23
Modify Date: 2025-09-26 11:29:54
GR125487 sulfamate is an orally active and selective antagonist of 5-HT4R. GR125487 sulfamate effectively blocks the cognition enhancing effect. GR125487 sulfamate can be used to study memory disorders, gastrointestinal disorders, mood disorders and urinary tract dysfunction[1].

Name	Sulfamic acid-(1-{2-[(methylsulfonyl)amino]ethyl}-4-piperidinyl )methyl 5-fluoro-2-methoxy-1H-indole-3-carboxylate (1:1)
Synonyms	[Ala92]-p16 (84-103)

Description	GR125487 sulfamate is an orally active and selective antagonist of 5-HT4R. GR125487 sulfamate effectively blocks the cognition enhancing effect. GR125487 sulfamate can be used to study memory disorders, gastrointestinal disorders, mood disorders and urinary tract dysfunction[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Nirogi, R., et al. Synthesis of GR 125487, a selective 5-HT4receptor antagonist. Synthetic Communications, 46(12), 1036–1043.