6013-57-6

6013-57-6 structure

Name: Arecaidine Hydrobromide
Chemical Name: 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrobromide
CAS Number: 6013-57-6
Molecular Formula: C₇H₁₂BrNO₂
Molecular Weight: 222.08
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2017-03-28 08:10:46
Modify Date: 2024-01-13 17:07:38
Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].

Name	1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrobromide
Synonyms	1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid,hydrobromide Nicotinic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide 3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide 1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure,Hydrochlorid 1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure,Hydrobromid Nicotinic acid,1,2,5,6-tetrahydro-1-methyl-,hydrobromide (8CI) 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid hydrobromide 1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid hydrobromide Arecaidine hydrobromide

Description	Arecaidine hydrobromide, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrobromide is a substrate of H+-coupled amino acid transporter 1 (PAT1, SLC36A1) and competitively inhibits L-proline uptake[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
References	[1]. D Lodge, et al. Effects of the Areca nut constituents arecaidine and guvacine on the action of GABA in the cat central nervous system. Brain Res. 1977 Nov 18;136(3):513-22. [2]. Valerie Voigt, et al. Transport of the areca nut alkaloid arecaidine by the human proton-coupled amino acid transporter 1 (hPAT1). J Pharm Pharmacol. 2013 Apr;65(4):582-90.

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6013-57-6

Literature: Freudenberg Chemische Berichte, 1918 , vol. 51, p. 1675