104557-24-6

104557-24-6 structure

Name: Desacetylcephapirin sodium
Chemical Name: Desacetyl Cephapirin Sodium Salt
CAS Number: 104557-24-6
Molecular Formula: C₁₅H₁₄N₃NaO₅S₂
Molecular Weight: 403.40900
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-12-28 23:00:18
Modify Date: 2024-01-05 11:13:32
Desacetylcephapirin sodium (Deacetylcephapirin sodium) is an active metabolite of Cephapirin (HY-A0153A). Desacetylcephapirin sodium has antimicrobial against S. aureus and coagulase-negative staphylococci mastitis pathogen[1][2].

Name	Desacetyl Cephapirin Sodium Salt
Synonyms	sodium,(6R,7R)-3-(hydroxymethyl)-8-oxo-7-[(2-pyridin-4-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Description	Desacetylcephapirin sodium (Deacetylcephapirin sodium) is an active metabolite of Cephapirin (HY-A0153A). Desacetylcephapirin sodium has antimicrobial against S. aureus and coagulase-negative staphylococci mastitis pathogen[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	antibacterial[2]
In Vitro	Desacetylcephapirin sodium exhibits inhibitory activity on Streptococcus dysgalactiae, with MIC50s both of 0.25 µg/mL for clinical and subclinical bacterial strain[2]. Desacetylcephapirin sodium exhibits inhibitory activity on coagulase-negative staphylococci mastitis pathogen, with MIC50s both of 0.12 µg/mL for clinical and subclinical bacterial strain[2].
References	[1]. B. E. Cabana, et al. Comparative Pharmacokinetics and Metabolism of Cephapirin in Laboratory Animals and Humans. Antimicrob Agents Chemother. 1976 Aug; 10(2): 307–317. [2]. Cristina S Cortinhas, et al. Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens. Am J Vet Res. 2013 May;74(5):683-90.