1072145-33-5
1072145-33-5 structure
- Name: ERRα antagonist-1
- Chemical Name: N-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-imine
- CAS Number: 1072145-33-5
- Molecular Formula: C21H19N3S2
- Molecular Weight: 377.52600
- Catalog: Research Areas Cancer
- Create Date: 2018-07-25 11:33:32
- Modify Date: 2024-04-05 17:21:41
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ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1].
| Name | N-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-3-(4,5-dihydro-1,3-thiazol-2-yl)-1,3-thiazolidin-2-imine |
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| Synonyms | N-(3-(4,5-Dihydrothiazol-2-yl)thiazolidin-2-ylidene)-5H-dibenzo[a,d][7]annulen-5-amine |
| Description | ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC50 values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1[1]. |
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| Related Catalog | |
| Target |
ERRα |
| References |
[1]. Michael J. Chisamore, et al. Identification of Small Molecule Estrogen-Related |
| Molecular Formula | C21H19N3S2 |
|---|---|
| Molecular Weight | 377.52600 |
| Exact Mass | 377.10200 |
| PSA | 78.56000 |
| LogP | 4.14090 |