Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4alpha-Phorbol12-myristate13-acetatesolid,
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: 4α-TPA
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

63597-44-4

63597-44-4 structure

63597-44-4 structure

Name: 4α-TPA
Chemical Name: 4α-Phorbol 12-myristate 13-acetate
CAS Number: 63597-44-4
Molecular Formula: C₃₆H₅₆O₈
Molecular Weight: 616.83
Catalog: Research Areas Cancer
Create Date: 2019-01-17 18:33:36
Modify Date: 2024-01-10 16:18:54
4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events[1].

Name	4α-Phorbol 12-myristate 13-acetate
Synonyms	Tetradecanoic acid, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester -yl ester 4-alpha-PMA (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-Acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl myristate Tetradecanoic acid, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9 MFCD00153860

Description	4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	TPA (5, 50, and 100 ng/ml; 24 hours), but not 4α-TPA, induces MMP-9 enzyme activity (MMP-9 zym) and mRNA expression (MMP-9 mRNA) in U87 cells[1].
References	[1]. Chiu WT, et al. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. Neurobiol Dis. 2010;37(1):118-129.

Density	1.2±0.1 g/cm3
Boiling Point	698.1±55.0 °C at 760 mmHg
Molecular Formula	C₃₆H₅₆O₈
Molecular Weight	616.83
Flash Point	208.1±25.0 °C
Exact Mass	616.397522
PSA	130.36000
LogP	7.71
Vapour Pressure	0.0±5.0 mmHg at 25°C
Index of Refraction	1.553

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3