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63597-44-4

63597-44-4 structure

63597-44-4 structure

Name: 4α-TPA
Chemical Name: 4α-Phorbol 12-myristate 13-acetate
CAS Number: 63597-44-4
Molecular Formula: C₃₆H₅₆O₈
Molecular Weight: 616.83
Catalog: Research Areas Cancer
Create Date: 2019-01-17 18:33:36
Modify Date: 2026-07-15 18:27:48
4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events[1].

Name	4α-Phorbol 12-myristate 13-acetate
Synonyms	4-ALPHA-12-TETRADECANOYL PHORBOL 13-ACETATE 4α-pma 4-alpha-Phorbol 12-Myristate 13-Acetate -yl ester 4-alpha-PMA, 4-alpha-TPA 4a-Phorbol 12-Myristate 13-Acetate 4-A-PHORBOL 12-MYRISTATE-13-ACETATE NEGA TIVE CONTROL (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-Acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl myristate Tetradecanoic acid, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9 4ALPHA-PHORBOL 12-MYRISTATE 13-ACETATE Tetradecanoic acid, (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl ester 4-alpha-PMA (1-1,1aα,1bβ,4,4a,7aα,7b,8,9,9a-Decahydro-4aα,7bα,9β,9aα-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8α-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one 9-myristate 9a-acetate Tetradecanoic acid,(1,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxyMethyl)-1,1,6,8-tetraMethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-ylester 4ALPHA-12-O-TETRADECANOYLPHORBOL 13-ACETATE 4-α-Phorbol-12-Myristate-13-acetate / 4-α-12-Tetradecanoyl phorbol-13-acetate 4ALPHA-PMA MFCD00153860 alpha-TPA 4ALPHA-TPA

Description	4α-TPA is an inactive form of TPA, and is used as a negative control for TPA-activated events[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	TPA (5, 50, and 100 ng/ml; 24 hours), but not 4α-TPA, induces MMP-9 enzyme activity (MMP-9 zym) and mRNA expression (MMP-9 mRNA) in U87 cells[1].
References	[1]. Chiu WT, et al. Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activation. Neurobiol Dis. 2010;37(1):118-129.

Density	1.2±0.1 g/cm3
Boiling Point	698.1±55.0 °C at 760 mmHg
Molecular Formula	C₃₆H₅₆O₈
Molecular Weight	616.83
Flash Point	208.1±25.0 °C
Exact Mass	616.397522
PSA	130.36000
LogP	7.71
Vapour Pressure	0.0±5.0 mmHg at 25°C
Index of Refraction	1.553

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