24730-31-2

24730-31-2 structure

Name: Surfactin
Chemical Name: surfactin C
CAS Number: 24730-31-2
Molecular Formula: C₅₃H₉₃N₇O₁₃
Molecular Weight: 1036.34000
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-07-23 09:47:21
Modify Date: 2024-01-04 10:33:00
Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects[1][2]. Surfactin also has antiviral activity against a variety of enveloped viruses[3].

Name	surfactin C
Synonyms	MFCD00082048

Description	Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. Surfactin can act as an antimicrobial adjuvant with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects[1][2]. Surfactin also has antiviral activity against a variety of enveloped viruses[3].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	HSV-1 HSV-2
In Vitro	Surfactin can increase the activity of Amoxicillin against avian pathogenic Escherichia coli (APEC) in vitro with antimicrobial assays such as minimum inhibitory concentrations (MIC) and fractional inhibitory concentration (FIC). For APEC O78 strain, the MIC of Amoxicillin and Surfactin are 1000 ug/ml and >1mg/ml, respectively[1].
In Vivo	In the model of chick infection (inoculation of E.coli), Surfactin exerts adjuvant effects with Amoxicillin against APEC by lowering the numerical value of mortality and liver bacterial loads, and regulating the expression of inflammatory cytokines et al. Surfactin can act as a novel antimicrobial adjuvant with Amoxicillin against AEPC infection in chicken[1].
References	[1]. Liu J, et al. Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin. PLoS One. 2019 Sep 12;14(9):e0222413. [2]. Wei-Chuan Chena, et al. Applications of a lipopeptide biosurfactant, surfactin, produced by microorganisms. Biochemical Engineering Journal. 103 (2015) 158-169. [3]. Vollenbroich D, et al. Mechanism of inactivation of enveloped viruses by the biosurfactant surfactin from Bacillus subtilis. Biologicals. 1997 Sep;25(3):289-97.

Density	1.037±0.06 g/cm3
Boiling Point	1268.3±65.0℃
Molecular Formula	C₅₃H₉₃N₇O₁₃
Molecular Weight	1036.34000
Exact Mass	1035.68000
PSA	304.60000
LogP	7.34390
Storage condition	2-8°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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