475591-59-4

475591-59-4 structure

Name: Boc-NH-PEG2-NH-Boc
Chemical Name: 1,8-di-(tert-butoxycarbonylamino)-3,6-dioxaoctane
CAS Number: 475591-59-4
Molecular Formula: C₁₆H₃₂N₂O₆
Molecular Weight: 348.43500
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-05-22 07:25:58
Modify Date: 2024-01-02 23:54:48
Boc-NH-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,8-di-(tert-butoxycarbonylamino)-3,6-dioxaoctane
Synonyms	MFCD08067562

Description	Boc-NH-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562