Henan Tianfu Chemical Co., Ltd.
China
Product Name: TIANFU-CHEM_Nafarelin 76932-56-4 99.0%
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76932-56-4

76932-56-4 structure

Name: (D-2-Nal6)-LHRH acetate salt
Chemical Name: Nafarelin
CAS Number: 76932-56-4
Molecular Formula: C₆₆H₈₃N₁₇O₁₃
Molecular Weight: 1322.471
Catalog: API Hormone and endocrine-regulating drugs Gonadotropin
Create Date: 2018-04-13 08:00:00
Modify Date: 2026-07-01 10:05:12
Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Sequence: {Glp}-His-Trp-Ser-Tyr-{2-Naph-Ala}-Leu-Arg-Pro-Gly-NH2.

Name	Nafarelin
Synonyms	(2S)-N-(2-amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-(2-methylpropyl)-8-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide (non-preferred name) RS-94991 Luteinizing hormone-releasing factor (swine), 6-[3-(2-naphthalenyl)-D-alanine] 6-(3-(2-naphthalenyl)-d-alanine)-luteinizinghormone-releasingfactor(pig (D-2-Nal6)-LHRH Nafelin Synel Nafelin (2S)-N-(2-Amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-isobutyl-8-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide (non-preferred name) AI3 6-(3-(2-Naphthalenyl)-D-alanine)luteinizing Hormone-releasing Factor Nafelina [spanish] Nafelin acetate salt N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(2-naphthalenyl)-1-oxopro Synarel C07613 Synrelina Lhrh, Ala(2-naphthyl) 6-(3-(2-naphthalenyl)-d-alanine)luteinizinghormone-releasingfactor(pig) 76-0 (Monoacetate (salt)) (D-2-NAL6)-LHRH Nacenyl Nafelin [inn:ban] 86-0 (Acetate (salt), hydrate) Nafelin Acetate, Nafelina Nafelin //BP 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-3-(2-naphtyl)-D-Ala-L-Leu-L-g-L-Pro-Gly-NH2 Nafelina AI314925 UNII:1X0094V6JV Nafarelin Acetate Nafeline Nasanyl RS-94991-298 Pyr-His-Trp-Ser-Tyr-D-2-Nal-Leu-g-Pro-Gly-NH2 acetate salt TIANFU-CHEM_Nafelin 76-4 Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine) PYR-HIS-TRP-SER-TYR-D-2-NAL-LEU-G-PRO-GLY-NH2 Nafelin Acetate\|(D-2-Nal6)-LHRH ala(2-naphthyl)-lhr Nafareline (2S)-N-(2-Amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-isobutyl-8-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxo-2-pyrrolidinyl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}-2-pyrrolidinecarboxamide AI3-14925

Description	Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Sequence: {Glp}-His-Trp-Ser-Tyr-{2-Naph-Ala}-Leu-Arg-Pro-Gly-NH2.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Peptides Research Areas >> Cancer
Target	GnRH[1].
In Vitro	Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)[1]. Nafarelin is used effectively in in vitro fertilisation programmes. Nafarelin is readily and rapidly absorbed following intranasal delivery, and is protected to some extent from enzymatic degradation GnRH[2].
References	[1]. Letassy NA et al. Nafarelin acetate: a gonadotropin-releasing hormone agonist for the treatment of endometriosis. DICP. 1990 Dec, 24(12):1204-9. [2]. Chrisp P et al. Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions.Drugs. 1990 Apr;39(4):523-51.

Density	1.5±0.1 g/cm3
Molecular Formula	C₆₆H₈₃N₁₇O₁₃
Molecular Weight	1322.471
Exact Mass	1321.635620
PSA	472.13000
LogP	0.89
Index of Refraction	1.711
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OK6371150

CHEMICAL NAME :: Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)-

CAS REGISTRY NUMBER :: 76932-56-4

LAST UPDATED :: 199703

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C66-H83-N17-O13

MOLECULAR WEIGHT :: 1322.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 448 ug/kg/8W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 347,333,1996

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