78957-84-3

78957-84-3 structure

Name: Calmodulin antagonist-1
Chemical Name: N-(4-aminobutyl)-5-chloronaphthalene-1-sulfonamide,hydrochloride
CAS Number: 78957-84-3
Molecular Formula: C₁₄H₁₈Cl₂N₂O₂S
Molecular Weight: 349.28
Catalog: Signaling Pathways Neuronal Signaling CaMK
Create Date: 2018-12-10 17:58:09
Modify Date: 2024-01-11 17:43:55
Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=375 μM) in a competitive fashion with respect to cyclic GMP and the Ki value is 300 μM[1].

Name	N-(4-aminobutyl)-5-chloronaphthalene-1-sulfonamide,hydrochloride
Synonyms	1-Butanaminium, 4-[[(5-chloro-1-naphthalenyl)sulfonyl]amino]-, chloride (1:1) N-(4-Aminobutyl)-5-chloronaphthalene-1-sulfonamide hydrochloride (1:1) N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride 4-{[(5-Chloro-1-naphthyl)sulfonyl]amino}-1-butanaminium chloride N-(4-Aminobutyl)-5-chloro-1-naphthalenesulphonamide hydrochloride OR0190T Calmodulin antagonist-1

Description	Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=375 μM) in a competitive fashion with respect to cyclic GMP and the Ki value is 300 μM[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Neuronal Signaling >> CaMK
References	[1]. Itoh H, et al. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J Biochem. 1984;96(6):1721-1726.

HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%