83546-42-3
83546-42-3 structure
- Name: 2'-Fluoro-5-ethylarabinosyluracil
- Chemical Name: 5-ethyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- CAS Number: 83546-42-3
- Molecular Formula: C11H15FN2O5
- Molecular Weight: 274.25
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
- Create Date: 2018-12-26 18:27:56
- Modify Date: 2024-01-09 00:09:17
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1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1].
| Name | 5-ethyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
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| Synonyms |
1-[5-(2-Fluoroethyl)-D-arabinopyranosyl]-2,4(1H,3H)-pyrimidinedione
FEAU 1-Dfafeu 1-(2-Deoxy-2-fluoroarabinofuranosyl)-5-ethyluracil 1-[(3S,4R,5S)-6-(2-Fluoroethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl]-2,4(1H,3H)-pyrimidinedione 2,4(1H,3H)-Pyrimidinedione, 1-[(5ξ)-6,7-dideoxy-7-fluoro-D-arabino-heptopyranosyl]- 1-[(5ξ)-6,7-Dideoxy-7-fluoro-D-arabino-heptopyranosyl]-2,4(1H,3H)-pyrimidinedione 2'-Fluoro-5-ethylarabinosyluracil 1-[(5ξ)-6,7-Dideoxy-7-fluoro-D-arabino-heptopyranosyl]pyrimidine-2,4(1H,3H)-dione |
| Description | 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1]. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C11H15FN2O5 |
| Molecular Weight | 274.25 |
| Exact Mass | 290.091400 |
| PSA | 124.78000 |
| LogP | -0.88 |
| Index of Refraction | 1.587 |
|
~91%
83546-42-3 |
| Literature: Journal of Organic Chemistry, , vol. 53, p. 85 - 88 |
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| Literature: Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 46, # 4 p. 285 - 289 |
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| Literature: Journal of Medicinal Chemistry, , vol. 30, # 5 p. 867 - 871 |
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| Literature: Journal of medicinal chemistry, , vol. 27, # 1 p. 91 - 94 |
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83546-42-3 |
| Literature: Journal of Organic Chemistry, , vol. 53, p. 85 - 88 |
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83546-42-3 |
| Literature: Journal of medicinal chemistry, , vol. 27, # 1 p. 91 - 94 |
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83546-42-3 |
| Literature: Journal of medicinal chemistry, , vol. 27, # 1 p. 91 - 94 |
| Precursor 6 | |
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| DownStream 1 | |
![4-amino-5-ethyl-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one structure](https://image.chemsrc.com/caspic/398/95740-17-3.png)