178870-32-1

178870-32-1 structure

Name: N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide
Chemical Name: N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methylfuran-3-carbothioamide
CAS Number: 178870-32-1
Molecular Formula: C₁₇H₁₈ClNO₂S
Molecular Weight: 335.84800
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2016-07-21 07:27:59
Modify Date: 2025-06-08 18:44:54
UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus (HIV)-1 with an IC50 value of 5 nM. UC-781 is stable under low pH or various temperatures conditions. UC-781 has antiviral activity and resistance[1][2][3].

Name	N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methylfuran-3-carbothioamide
Synonyms	2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE N-[4-Chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide Thiocarboxanilide UC-781 UC1

Description	UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of human immunodeficiency virus (HIV)-1 with an IC50 value of 5 nM. UC-781 is stable under low pH or various temperatures conditions. UC-781 has antiviral activity and resistance[1][2][3].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1:0.005 μM (IC50)
In Vitro	UC-781 (0.05、0.2 和 0.5 % UC-781 补充凝胶；10 天) 从凝胶制剂中释放出来，并清除 CEM 感染细胞中的人类免疫缺陷病毒 (HIV)-1[1]。 UC-781 (3.75 -30 μM) 抑制蜡样芽孢杆菌的生长 (大约 50 %)[1]。 UC-781 抑制 CEM T 细胞中的 HIV-1 (ⅢB) (EC50=6 nM; IC50=23 nM)。UC-781 抑制单核细胞来源的树突状细胞 (MO-DC) 和自体 CD4+ T 细胞，EC50 值分别为 550 nM 和 1588 nM[2]。 UC-781 (1000 nM；24 h) 有效地防止或阻止了单核细胞来源的树突状细胞和自体 CD4+ T 细胞感染 HIV[2]。 UC-781 (0.001-1000 µM；2 h) 抑制病毒 (virus) 转移和宫颈外植体感染 HIV-1BaL[4]。
In Vivo	UC-781 (100 µl 5% UC-781 补充凝胶；阴道内；一天一次持续 10 天) 从凝胶制剂中释放出来，对正常组织显示低毒性[1]。 Animal Model: Female rabbit (~1200 g; 10 weeks old)[1]. Dosage: 100 µl 5% UC-781 replens gel. Administration: Intravaginal; once daily for 10 days. Result: Released from gel preparation and had normal histology without significant increases inflammatory cells in rabbits.
References	[1]. Balzarini J, et al. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS. 1998 Jul 9;12(10):1129-38. [2]. Van Herrewege Y, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9. [3]. Balzarini J, et al. Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. Mol Pharmacol. 1996 Aug;50(2):394-401. [4]. Fletcher P, et al. The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol. 2005 Sep;79(17):11179-86.

Density	1.24g/cm3
Boiling Point	440.9ºC at 760mmHg
Molecular Formula	C₁₇H₁₈ClNO₂S
Molecular Weight	335.84800
Flash Point	220.4ºC
Exact Mass	335.07500
PSA	66.49000
LogP	5.44700
Vapour Pressure	5.68E-08mmHg at 25°C
Index of Refraction	1.621

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2138139-94-1	2228977-61-3
2228829-97-6	2167263-19-4
2138232-52-5	105945-76-4
2228344-43-0	2760568-81-6
208333-73-7	2228119-16-0