568565-11-7

568565-11-7 structure

Name: (Ala13)-Apelin-13 (human, bovine, mouse, rat) acetate salt
Chemical Name: h-gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-ala-oh
CAS Number: 568565-11-7
Molecular Formula: C₆₃H₁₀₇N₂₃O₁₆S
Molecular Weight: 1474.73000
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-12-30 02:02:48
Modify Date: 2024-01-05 13:03:57
(Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway[1].

Name	h-gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-ala-oh
Synonyms	qrprlshkgpmpa GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-ALA (Ala13)-Apelin-13 (human, bovine, mouse, rat)

Description	(Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway[1].
Related Catalog	Research Areas >> Cardiovascular Disease
In Vivo	(Ala13)-Apelin-13 (1-300 pmol/60 nl；显微注射到 DVC 中) 以剂量依赖性方式降低大鼠的胃张力和胃动力[1]。 Animal Model: 250-300 g, Sprague-Dawley rats[1] Dosage: 1-300 pmol/60 nl Administration: Microinjected into the DVC (dorsal vagal complex (DVC) Result: Decreased gastric tone and motility in a dose-dependent manner with D50 ≈ 27 pmol for both antrum and corpus.
References	[1]. Bülbül M, et al. Apelin-13 inhibits gastric motility through vagal cholinergic pathway in rats. Am J Physiol Gastrointest Liver Physiol. 2018 Feb 1;314(2):G201-G210.