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489427-26-1

489427-26-1 structure
489427-26-1 structure
  • Name: Fmoc-NH-PEG3-amide-CH2OCH2COOH
  • Chemical Name: 17-(Fmoc-amino)-5-oxo-6-aza-3,9,12,15-tetraoxaheptadecanoic Acid
  • CAS Number: 489427-26-1
  • Molecular Formula: C27H34N2O9
  • Molecular Weight: 530.56700
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-11-06 10:29:05
  • Modify Date: 2024-01-08 12:43:13
  • Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 17-(Fmoc-amino)-5-oxo-6-aza-3,9,12,15-tetraoxaheptadecanoic Acid
Synonyms 2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid
Description Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.256g/cm3
Boiling Point 794.8ºC at 760 mmHg
Molecular Formula C27H34N2O9
Molecular Weight 530.56700
Flash Point 434.5ºC
Exact Mass 530.22600
PSA 141.65000
LogP 2.57410
Index of Refraction 1.558
Storage condition 2-8°C
Precursor  3

DownStream  0