Name | 17-(Fmoc-amino)-5-oxo-6-aza-3,9,12,15-tetraoxaheptadecanoic Acid |
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Synonyms | 2-[2-[2-[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid |
Description | Fmoc-NH-PEG3-amide-CH2OCH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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Related Catalog | |
Target |
PEGs |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
References |
Density | 1.256g/cm3 |
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Boiling Point | 794.8ºC at 760 mmHg |
Molecular Formula | C27H34N2O9 |
Molecular Weight | 530.56700 |
Flash Point | 434.5ºC |
Exact Mass | 530.22600 |
PSA | 141.65000 |
LogP | 2.57410 |
Index of Refraction | 1.558 |
Storage condition | 2-8°C |
~84% 489427-26-1 |
Literature: AMERSHAM HEALTH AS Patent: WO2006/4429 A2, 2006 ; Location in patent: Page/Page column 14 ; |
~% 489427-26-1 |
Literature: Lindner, Simon; Michler, Christina; Leidner, Stephanie; Rensch, Christian; Waengler, Carmen; Schirrmacher, Ralf; Bartenstein, Peter; Waengler, Bjoern Bioconjugate Chemistry, 2014 , vol. 25, # 4 p. 738 - 749 |
~% 489427-26-1 |
Literature: Lindner, Simon; Michler, Christina; Leidner, Stephanie; Rensch, Christian; Waengler, Carmen; Schirrmacher, Ralf; Bartenstein, Peter; Waengler, Bjoern Bioconjugate Chemistry, 2014 , vol. 25, # 4 p. 738 - 749 |
Precursor 3 | |
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DownStream 0 |