1314230-75-5
1314230-75-5 structure
- Name: CB2 receptor agonist 2
- Chemical Name: 4-Quinolone-3-Carboxamide Furan CB2 Agonist
- CAS Number: 1314230-75-5
- Molecular Formula: C30H36N2O4
- Molecular Weight: 488.618
- Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
- Create Date: 2017-05-06 03:07:52
- Modify Date: 2024-01-16 18:05:14
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CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2[1].
| Name | 4-Quinolone-3-Carboxamide Furan CB2 Agonist |
|---|---|
| Synonyms |
2ne1
apica N-(Adamantan-1-yl)-6-(2-furyl)-8-methoxy-4-oxo-1-pentyl-1,4-dihydro-3-quinolinecarboxamide 3-Quinolinecarboxamide, 6-(2-furanyl)-1,4-dihydro-8-methoxy-4-oxo-1-pentyl-N-tricyclo[3.3.1.1]dec-1-yl- sdb-001 |
| Description | CB2 receptor agonist 2 is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor with a Ki of 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2[1]. |
|---|---|
| Related Catalog | |
| Target |
CB2:8.5 nM (Ki) |
| In Vitro | CB2 receptor agonist 2 (compound 4g) (1 μM; 72 hours) has very low or no cytotoxicity to Hep-G2 cells[1]. Cell Proliferation Assay[1] Cell Line: Hep-G2 (Human hepatoblastoma) cells Concentration: 1 μM Incubation Time: 72 hours Result: Exhibited very low or no cytotoxicity to Hep-G2 cells. |
| In Vivo | CB2 receptor agonist 2 (compound 4g) (1 and 3 mg/kg; 1 hour) is very potent (with maximal effect being reached already at the 1 mg/kg dose) and has antihyperalgesic effects, efficacious also on the first phase of the nocifensive response and strongly reduced by AM630 (CB2-selective antagonist/inverse agonist) [1]. Animal Model: Formalin injection induces a biphasic stereotypical nocifensive behavior in mice[1] Dosage: Formalin (1.25% in saline, 30 μL), 1 and 3 mg/kg CB2 receptor agonist 2, 1 mg/kg AM630, monitor every 5 minutes for 1 hour Administration: Injection in the dorsal surface of one side of the hindpaw (Formalin), i.p. (CB2 receptor agonist, AM630) Result: Elicited antihyperalgesic effects and potent (with maximal effect being reached already at the 1 mg/kg dose) and efficacious, strongly reduced by AM630. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 674.1±55.0 °C at 760 mmHg |
| Molecular Formula | C30H36N2O4 |
| Molecular Weight | 488.618 |
| Flash Point | 361.5±31.5 °C |
| Exact Mass | 488.267517 |
| PSA | 73.47000 |
| LogP | 5.80 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.623 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
