503612-76-8
503612-76-8 structure
- Name: O-Desmethyl apixaban
- Chemical Name: 1-(4-hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide
- CAS Number: 503612-76-8
- Molecular Formula: C24H23N5O4
- Molecular Weight: 445.47100
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-10-11 22:39:45
- Modify Date: 2024-02-06 19:37:52
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O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01)[1]. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2].
| Name | 1-(4-hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide |
|---|---|
| Synonyms |
4-Demethoxy-4-hydroxy Apixaban
O-demethyl-apixaban Apixaban Impurity 18 |
| Description | O-Desmethyl apixaban is a metabolite of Apixaban (BMS-562247-01)[1]. Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C24H23N5O4 |
|---|---|
| Molecular Weight | 445.47100 |
| Exact Mass | 445.17500 |
| PSA | 122.75000 |
| LogP | 3.41080 |
|
~6%
503612-76-8 |
| Literature: Pinto, Donald J.P.; Quan, Mimi L.; Orwat, Michael J.; Li, Yun-Long; Han, Wei; Qiao, Jennifer X.; Lam, Patrick Y.S.; Koch, Stephanie L. Patent: US2003/191115 A1, 2003 ; |
| Precursor 1 | |
|---|---|
| DownStream 0 | |