59988-01-1

59988-01-1 structure

Name: NSC 243928
Chemical Name: N-[4-(acridin-9-ylamino)-3-methoxyphenyl]ethanesulfonamide,methanesulfonic acid
CAS Number: 59988-01-1
Molecular Formula: C₂₃H₂₅N₃O₆S₂
Molecular Weight: 503.59100
Catalog: Research Areas Cancer
Create Date: 2018-06-21 15:02:20
Modify Date: 2024-01-03 22:13:28
NSC243928 mesylate is a human lymphocyte antigen 6 (LY6) binder, which also acts as an inhibitor of cell growth and has anticancer activity[1].

Name	N-[4-(acridin-9-ylamino)-3-methoxyphenyl]ethanesulfonamide,methanesulfonic acid
Synonyms	Ethanesulfonamide,N-(4-(9-acridinylamino)-3-methoxyphenyl)-,monomethanesulfonate Ethanesulfonamide,N-(4-(acridinyl-9-ylamino)-3-methoxyphenyl)-,methanesulfonate 4'-(9-Acridinylamino)-3'-methoxyethanesulfonanilide methanesulfonate Ethanesulfonamide,monomethanesulfonate Ethanesulfonanilide,4'-(9-acridinylamino)-3'-methoxy-,methanesulfonate

Description	NSC243928 mesylate is a human lymphocyte antigen 6 (LY6) binder, which also acts as an inhibitor of cell growth and has anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	NSC243928 mesylate (2 μM, 24 h) 可以诱导 MDA-MB-231 对照细胞死亡，而在 LY6K 敲低细胞中显示细胞活力增加，进而表明 NSC243928 可能通过 LY6K 途径诱导细胞死亡[1]。 NSC243928 mesylate 作用于MDA-MB-231，Hs-578-T，BT-549，OVCAR-8 细胞的 IC50 值分别是 5.683 μM，7.309 μM，7.954 μM 和 4.167 μM[1]。
References	[1]. Senyi Benti, et al. Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death. Cancers (Basel). 2020 Feb 22;12(2):509.