6192-43-4
6192-43-4 structure
- Name: HJ-PI01
- Chemical Name: 1-phenoxazin-10-ylethanone
- CAS Number: 6192-43-4
- Molecular Formula: C14H11NO2
- Molecular Weight: 225.24300
- Catalog: Signaling Pathways JAK/STAT Signaling Pim
- Create Date: 2017-08-26 15:50:56
- Modify Date: 2024-01-06 08:44:44
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HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research[1].
| Name | 1-phenoxazin-10-ylethanone |
|---|---|
| Synonyms |
UNII-VVA9DLS3TV
10-Acetyl-phenoxazin N-Acetylphenoxazine Phenoxazine,10-acetyl 10-acetyl-phenoxazine 10-acetyl-10H-phenoxazine |
| Description | HJ-PI01 (10-Acetylphenoxazine) is an orally active Pim-2 inhibitor. HJ-PI01 induces apoptosis and autophagic cell death of cancer cells. HJ-PI01 inhibits tumor growth in MDA-MB-231 xenograft mice. HJ-PI01 can be used for cancer research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | HJ-PI01 (0-3200 nmol/L；48 小时) 剂量性依赖地抑制 MDA-MB-231 细胞生长，与氯丙嗪和 PI003 相比效果更为显著改善[1]。 HJ-PI01 (100-400 nmol/L；24 小时) 对正常非癌细胞显示弱毒性[1]。 HJ-PI01 (300 nmol/L；24 小时) 诱导 MDA-MB-231 细胞自噬性细胞死亡[1]。 HJ-PI01 (300 nmol/L；24 小时) 诱导 MDA-MB-231 细胞凋亡性死亡[1]。 HJ-PI01 (300 和 460 nmol/L；12-48 小时) 影响自噬和凋亡相关蛋白的表达水平[1]。 Western Blot Analysis[1] Cell Line: MDA-MB-231 cell line Concentration: 300 and 460 nmol/L Incubation Time: 12, 24, 36 and 48 hours Result: Time-dependently increased LC3-II and Beclin-1 and induced p62 degradation in MDA-MB-231 cells. Increased the level of Bax. Decreased the level of Bcl-2, and Pim-2 and Pim-2 phosphorylation. Activated caspase-9 and caspase-3. |
| In Vivo | HJ-PI01 (40 mg/kg；口服，每日 1 次，持续 10 天) 抑制 MDA-MB-231 异种移植小鼠肿瘤生长[1]。 Animal Model: BALB/c female nude mice with MDA-MB-231 cells injection[1] Dosage: 40 mg/kg Administration: Oral administration; 40 mg/kg, once daily for 10 days Result: Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice. |
| References |
| Molecular Formula | C14H11NO2 |
|---|---|
| Molecular Weight | 225.24300 |
| Exact Mass | 225.07900 |
| PSA | 29.54000 |
| LogP | 3.54190 |
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~92%
6192-43-4 |
| Literature: Thome, Isabelle; Bolm, Carsten Organic Letters, 2012 , vol. 14, # 7 p. 1892 - 1895 |
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6192-43-4 |
| Literature: Thome, Isabelle; Bolm, Carsten Organic Letters, 2012 , vol. 14, # 7 p. 1892 - 1895 |
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6192-43-4 |
| Literature: Thome, Isabelle; Bolm, Carsten Organic Letters, 2012 , vol. 14, # 7 p. 1892 - 1895 |
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6192-43-4 |
| Literature: Thome, Isabelle; Bolm, Carsten Organic Letters, 2012 , vol. 14, # 7 p. 1892 - 1895 |
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~44%
6192-43-4 |
| Literature: Hernandez-Olmos, Victor; Abdelrahman, Aliaa; El-Tayeb, Ali; Freudendahl, Diana; Weinhausen, Stephanie; Mueller, Christa E. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 9576 - 9588 |
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6192-43-4 |
| Literature: Mueller et al. Journal of Organic Chemistry, 1959 , vol. 24, p. 37 |
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6192-43-4 |
| Literature: Mueller et al. Journal of Organic Chemistry, 1959 , vol. 24, p. 37 |
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6192-43-4 |
| Literature: Vanderhaeghe,H. Journal of Organic Chemistry, 1960 , vol. 25, p. 747 - 753 Full Text View citing articles Show Details Mueller et al. Journal of Organic Chemistry, 1959 , vol. 24, p. 37 |
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6192-43-4 |
| Literature: Kehrmann; Saager Chemische Berichte, 1903 , vol. 36, p. 481 |
