54632-04-1

54632-04-1 structure

Name: (4aα)-2-Methylene-5,5,8aβ-trimethyldecalin-1β-methanol
Chemical Name: [(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]methanol
CAS Number: 54632-04-1
Molecular Formula: C₁₅H₂₆O
Molecular Weight: 222.36600
Catalog: Research Areas Cancer
Create Date: 2016-06-01 04:32:23
Modify Date: 2024-01-02 20:02:19
Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. Albicanol shows cytotoxicity. Albicanol suppress profenofos (HY-B0832) induced genotoxicity in grass carp hepatocytes[1][2].

Name	[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]methanol
Synonyms	Albicanol

Description	Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. Albicanol shows cytotoxicity. Albicanol suppress profenofos (HY-B0832) induced genotoxicity in grass carp hepatocytes[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Albicanol (compound 6) (0-30 µM; 48 h) 显示细胞毒性，对 A549、MCF7、HepG2 细胞的 IC50 值分别 >30、24.14、>30 µM[1 ]. Albicanol (0.00005 µg/mL; 24 h) 显着抑制 L8824 细胞因 PFF 暴露而产生的遗传毒性[2]。 Cell Cytotoxicity Assay[1] Cell Line: A549, MCF7, HepG2 cells Concentration: 0-30 µM Incubation Time: 48 h Result: Showed cytotoxicity with IC50s of >30, 24.14, >30 µM for A549, MCF7, HepG2 cells, respectively.
References	[1]. Zhao DD, et al. Compounds from Dryopteris fragrans (L.) Schott with cytotoxic activity. Molecules. 2014 Mar 18;19(3):3345-55. [2]. Lihui X, et al. Albicanol modulates oxidative stress and the p53 axis to suppress profenofos induced genotoxicity in grass carp hepatocytes. Fish Shellfish Immunol. 2022 Mar;122:325-333.

HS Code	2906199090

Precursor 0
DownStream 1
3243-36-5

HS Code	2906199090
Summary	2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%