199396-76-4

199396-76-4 structure

Name: Asoprisnil
Chemical Name: (8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number: 199396-76-4
Molecular Formula: C₂₈H₃₅NO₄
Molecular Weight: 449.58200
Catalog: Research Areas Endocrinology
Create Date: 2017-12-21 05:56:45
Modify Date: 2024-01-16 10:35:21
Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human[1].

Name	(8S,11R,13S,14S,17S)-11-[4-[(E)-hydroxyiminomethyl]phenyl]-17-methoxy-17-(methoxymethyl)-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Synonyms	J867 Benzaldehyde,4-((11beta,17beta)-17-methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl)-,1-oxime,(C(E)) Asoprisnil 11beta-(4-((E)-(Hydroxyimino)methyl)phenyl)-17beta-methoxy-17-(methoxymethyl)estra-4,9-dien-3-one Asoprisnil (USAN/INN)

Description	Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human[1].
Related Catalog	Signaling Pathways >> Others >> Progesterone Receptor Research Areas >> Endocrinology
References	[1]. Stewart EA, et al. Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials. Hum Reprod. 2019 Apr 1;34(4):623-634. [2]. Wu XL, et al. Postcoital administration of asoprisnil inhibited embryo implantation and disturbed ultrastructure of endometrium in implantation window in mice. J Huazhong Univ Sci Technolog Med Sci. 2013 Apr;33(2):277-283.