Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Indobufen
Price: ￥576.0/25mg ￥326.0/5mg
Purity: 97.0%
Stocking Period: 1 Day
Contact: Liu jia

Zhejiang Hangyu API Co., Ltd
China
Product Name: Indobufen
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

63610-08-2

63610-08-2 structure

Name: Indobufen
Chemical Name: 2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]butanoic acid
CAS Number: 63610-08-2
Molecular Formula: C₁₈H₁₇NO₃
Molecular Weight: 295.33
Catalog: API Blood system medication Anticoagulant and antiplatelet drugs
Create Date: 2018-08-09 11:34:32
Modify Date: 2024-01-02 11:41:31
Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes[1].

Name	2-[4-(3-oxo-1H-isoindol-2-yl)phenyl]butanoic acid
Synonyms	4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-benzeneacetic acid Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-, (±)- (±)-4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-a-ethylbenzeneacetic Acid 2-[4-(1-Oxo-1,3-dihydro-isoindol-2 MFCD00572250 2-[4-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]butanoic acid Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl- K-3920 UNII-6T9949G4LZ 1-Oxo-2-[p-[(a-ethyl)carboxymethyl]phenyl]isoindoline EINECS 264-364-4 2-(4-(1-Oxo-2-isoindolinyl)phenyl)butyric acid Ibustrin 1-Oxo-2-(p-((α-ethyl)carboxymethyl)phenyl)isoindoline 2-[4-(1-Carboxypropyl)phenyl]-1-isoindolinone (±)-2-[p-(1-Oxo-2-isoindolinyl)phenyl]butyric Acid Butyric acid, 2-(p-(1-oxo-2-isoindolinyl)phenyl)-, (±)- Indobufen 2-[4-(1-oxo-1,3-dihydro-isoindol-2-yl)-phenyl]-butyric acid 2-(4-(1-oxoisoindolin-2-yl)phenyl)butanoic acid Indobufen (INN) (±)-2-(p-(1-Oxo-2-isoindolinyl)phenyl)butyric acid

Description	Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX
In Vitro	Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels. Indobufen inhibits TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen reduces the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered[1].
References	[1]. Eligini S, et al. Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism. Cardiovasc Res. 2006 Jan;69(1):218-26.

Density	1.3±0.1 g/cm3
Boiling Point	518.1±50.0 °C at 760 mmHg
Melting Point	33-34 °C(lit.)
Molecular Formula	C₁₈H₁₇NO₃
Molecular Weight	295.33
Flash Point	267.1±30.1 °C
Exact Mass	295.120850
PSA	57.61000
LogP	3.30
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.630

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ET5955800

CHEMICAL NAME :: Butyric acid, 2-(p-(1-oxo-2-isoindolinyl)phenyl)-, (+-)-

CAS REGISTRY NUMBER :: 63610-08-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C18-H17-N-O3

MOLECULAR WEIGHT :: 295.36

WISWESSER LINE NOTATION :: T56 BVN DHJ CR DY2&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 373 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 333 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 697 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 365 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,109,1979

WGK Germany	3
HS Code	2942000000

HS Code	2918300090
Summary	2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

63610-08-2	36690-96-7
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