168266-51-1

168266-51-1 structure

Name: Vofopitant dihydrochloride
Chemical Name: (2S,3S)-N-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]-2-phenylpiperidin-3-amine,dihydrochloride
CAS Number: 168266-51-1
Molecular Formula: C₂₁H₂₅Cl₂F₃N₆O
Molecular Weight: 505.36400
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2016-01-15 09:28:13
Modify Date: 2024-01-31 05:30:02
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1].

Name	(2S,3S)-N-[[2-methoxy-5-[5-(trifluoromethyl)tetrazol-1-yl]phenyl]methyl]-2-phenylpiperidin-3-amine,dihydrochloride
Synonyms	Vofopitant dihydrochloride (USAN) Vofopitant hydrochloride Vofopitant HCl

Description	Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	pKi: 9.5 (NK1, rat), 10.6 (NK1, human)[1]
References	[1]. Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53.