Name | 3-pyridin-3-ylpropyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate |
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Synonyms |
L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-, 3-(3-pyridinyl)propyl ester
GPI (S)-3-(Pyridin-3-yl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate 3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)-L-prolinate gpi-1046 |
Description | GPI-1046 is a immunophilin ligand without antibiotic action and attenuates ethanol intake in part through the upregulation of glutamate transporter 1 (GLT1) in PFC and NAc-core. GPI-1046 is an analog of FK506, which is an immunophilin ligand that has been shown neuroprotective effects in neurodegenerative disease models[1]. GPI-1046 readily crosses the blood-brain barrier and promotes the regeneration of dopamine (DA) cells in the CNS in association with functional recovery in rodent models[2]. |
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Related Catalog | |
Target |
GLT1 |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 501.5±60.0 °C at 760 mmHg |
Molecular Formula | C20H28N2O4 |
Molecular Weight | 360.447 |
Flash Point | 257.1±32.9 °C |
Exact Mass | 360.204895 |
PSA | 90.40000 |
LogP | 1.54 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.529 |
HS Code | 2933990090 |
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HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |