144245-52-3

144245-52-3 structure

Name: Fomivirsen
Chemical Name: Fomivirsen
CAS Number: 144245-52-3
Molecular Formula: C₂₀₄H₂₆₃N₆₃O₁₁₄P₂₀S₂₀
Molecular Weight: 6682.40000
Catalog: Signaling Pathways Anti-infection CMV
Create Date: 2018-06-20 09:08:27
Modify Date: 2024-01-03 19:53:04
Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation[1][2].

Name	Fomivirsen
Synonyms	Isis 2922

Description	Fomivirsen (ISIS-2922 free base) is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen binds to and degrades the mRNAs encoding CMV immediate-early 2 protein, thus inhibiting virus proliferation[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> CMV
References	[1]. M D de Smet, et al. Fomivirsen- a phosphorothioate oligonucleotide for the treatment of CMV retinitis. Ocul Immunol Inflamm. 1999 Dec;7(3-4):189-98. [2]. Anna Kilanowska, et al. In vivo and in vitro studies of antisense oligonucleotides – a review. (Review Article) RSC Adv., 2020, 10, 34501-34516.