112559-91-8
112559-91-8 structure
- Name: Hydroxy Itraconazole
- Chemical Name: Hydroxy Itraconazole
- CAS Number: 112559-91-8
- Molecular Formula: C35H38Cl2N8O5
- Molecular Weight: 721.63
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2018-07-26 17:59:33
- Modify Date: 2026-07-09 16:57:17
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Itraconazole metabolite Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.
| Name | Hydroxy Itraconazole |
|---|---|
| Synonyms |
Itraconazole 2-Hydroxy Metabolite
Itraconazole Impurity 8(Hydroxy Itraconazole) 4-(4-(4-(4-((2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-(3-hydroxybutan-2-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one Itraconazole Impurity 1 Ketoconazole Impurity 36 2H6]-Hydroxyitraconazole Itraconazole metabolite Hydroxy Itraconazole HYDROXY ITRACONAZOLE Hydroxy ItraconazoleQ: What is Hydroxy Itraconazole Q: What is the CAS Number of Hydroxy Itraconazole Q: What is the storage condition of Hydroxy Itraconazole Q: What e the applications of Hydroxy Itraconazole Hydroxy Itraconazole D8Q: What is Hydroxy Itraconazole D8 Q: What is the CAS Number of Hydroxy Itraconazole D8 Q: What is the storage condition of Hydroxy Itraconazole D8 Q: What e the applications of Hydroxy Itraconazole D8 3H-1,2,4-Triazol-3-one, -2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl) 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl) Hydroxy Itraconazole (10mM in DMSO) Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole |
| Description | Itraconazole metabolite Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent. |
|---|---|
| Related Catalog | |
| Target |
Antifungal[1] |
| In Vitro | Hydroxy Itraconazole (OH-ITZ) is an active metabolite of Itraconazole (ITZ). Although OH-ITZ is also reported to have antifungal activity in vitro, its pharmacokinetics in humans has been studied less than that of ITZ. ITZ and OH-ITZ have a triazole ring and inhibit CYP3A. Their half-lives can be extended by 26-60% with repeated administration compared to single administration[1]. |
| In Vivo | The plasma concentration of OH-ITZ is weakly dependent on the dose of ITZ, most likely because the process that forms OH-ITZ is saturated. Serum albumin and GFR may alter the pharmacokinetics of ITZ and OH-ITZ. Antifungal activity should be discussed while taking into account not only the plasma concentration of ITZ but also that of OH-ITZ. However, the pharmacokinetics of OH-ITZ is similar to that of ITZ in immunocompromised patients taking an oral solution of ITZ. Since the plasma concentrations of ITZ and OH-ITZ are closely correlated, determining the plasma concentration of either should be sufficient from a clinical point of view[1]. |
| References |
| Density | 1.44g/cm3 |
|---|---|
| Boiling Point | 884.7ºC at 760mmHg |
| Melting Point | 76-78ºC |
| Molecular Formula | C35H38Cl2N8O5 |
| Molecular Weight | 721.63 |
| Flash Point | 488.8ºC |
| PSA | 103.95000 |
| LogP | 4.96710 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.687 |
| Storage condition | 2-8℃ |