245342-14-7
245342-14-7 structure
- Name: LED209
- Chemical Name: 1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thiourea
- CAS Number: 245342-14-7
- Molecular Formula: C19H17N3O2S2
- Molecular Weight: 383.487
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2016-01-31 08:49:39
- Modify Date: 2024-01-08 15:35:23
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LED209 is a potent small molecule inhibitor of bacterial receptor QseC, is a potent prodrug that is highly selective for QseC. Target: AntibacterialLED209 has desirable pharmacokinetics and does not present toxicity in vitro and in rodents. This is a unique antivirulence approach, with a proven broad-spectrum activity against multiple Gram-negative pathogens that cause mammalian infections.The LED209 QseC inhibitor has a unique mode of action by acting as a prodrug scaffold to deliver a warhead that allosterically modifies QseC, impeding virulence in several Gram-negative pathogens.[1] LED209 is QseC sensor kinase inhibitor , as a potential lead compound to combat infections with Legionella or Mycobacterium spp. [2] LED209 inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 inhibits EHEC virulence traits in vitro. LED209 markedly inhibits the virulence of several pathogens in animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs. [3]
| Name | 1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thiourea |
|---|---|
| Synonyms |
LED209 hydrate
Benzenesulfonamide, N-phenyl-4-[[(phenylamino)thioxomethyl]amino]- N-Phenyl-4-(3-phenylthioureido)benzenesulfonamide N-Phenyl-4-[(phenylcarbamothioyl)amino]benzenesulfonamide N-phenyl-4-[[(phenylamino)thioxomethyl]amino]benzenesulfonamide hydrate LED209 |
| Description | LED209 is a potent small molecule inhibitor of bacterial receptor QseC, is a potent prodrug that is highly selective for QseC. Target: AntibacterialLED209 has desirable pharmacokinetics and does not present toxicity in vitro and in rodents. This is a unique antivirulence approach, with a proven broad-spectrum activity against multiple Gram-negative pathogens that cause mammalian infections.The LED209 QseC inhibitor has a unique mode of action by acting as a prodrug scaffold to deliver a warhead that allosterically modifies QseC, impeding virulence in several Gram-negative pathogens.[1] LED209 is QseC sensor kinase inhibitor , as a potential lead compound to combat infections with Legionella or Mycobacterium spp. [2] LED209 inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 inhibits EHEC virulence traits in vitro. LED209 markedly inhibits the virulence of several pathogens in animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs. [3] |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 549.4±60.0 °C at 760 mmHg |
| Molecular Formula | C19H17N3O2S2 |
| Molecular Weight | 383.487 |
| Flash Point | 286.1±32.9 °C |
| Exact Mass | 383.076202 |
| PSA | 110.70000 |
| LogP | 3.40 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.741 |
| Storage condition | 2-8℃ |