606968-52-9

606968-52-9 structure

Name	fc 131
Synonyms	Cyclo[3-(2-naphthalenyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl] Cyclo[3-(2-naphthyl)-L-alanylglycyl-D-tyrosyl-L-arginyl-L-arginyl] Cyclo[3-(2-naphthyl)-D-alanylglycyl-D-tyrosyl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-L-ornithyl] Cyclo[3-(2-naphthalenyl)-D-alanylglycyl-D-tyrosyl-N-(diaminomethylene)-L-ornithyl-N-(diaminomethylene)-L-ornithyl] 1',2-{[(2S,5S,8S,14R)-14-(4-hydroxybenzyl)-8-(naphthalen-2-ylmethyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecane-2,5-diyl]dipropane-3,1-diyl}diguanidine (non-preferred name)

Description	FC131 TFA 是一种 CXCR4 拮抗剂，抑制 [125I]-SDF-1 与 CXCR4 结合，IC50 值为 4.5 nM。FC131 TFA 具有抗 HIV 的活性。
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	125I-SDF-CXCR4:4.5 nM (IC50) HIV
References	[1]. Tamamura H, et al. Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogues of the CXCR4 antagonist FC131. J Med Chem. 2005 Jan 27;48(2):380-91.