949021-68-5
949021-68-5 structure
- Name: Sodium formononetin-3'-sulfonate
- Chemical Name: 5-(7-hydroxy-4-oxochromen-3-yl)-2-methoxybenzenesulfonic acid, sodium
- CAS Number: 949021-68-5
- Molecular Formula: C16H11NaO7S
- Molecular Weight: 370.31
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2016-08-04 13:17:44
- Modify Date: 2024-01-03 08:39:56
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Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol. derivate of formononetin. IC50 value:Target: Research results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase and cardiac troponin T in serum and reduced the myocardium necrosis scores. These findings indicate that Sul-F has a protective potential against myocardial infarction injury. A possible mechanism for the protective effect is the elevated expression of endogenous antioxidant defense enzymes degraded lipid peroxidn. products and improved energy metab. of cardiac mitochondrial, thus attenuating cardiocyte apoptosis. Other reaearch results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities.
| Name | 5-(7-hydroxy-4-oxochromen-3-yl)-2-methoxybenzenesulfonic acid, sodium |
|---|---|
| Synonyms |
Sodium formononetin-3'-sulfonate
sodium 4'-methoxy-7-hydroxyisoflavone-3'-sulfonate CS-0865 |
| Description | Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol. derivate of formononetin. IC50 value:Target: Research results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of creatine kinase-MB, lactate dehydrogenase, alanine aminotransferase and cardiac troponin T in serum and reduced the myocardium necrosis scores. These findings indicate that Sul-F has a protective potential against myocardial infarction injury. A possible mechanism for the protective effect is the elevated expression of endogenous antioxidant defense enzymes degraded lipid peroxidn. products and improved energy metab. of cardiac mitochondrial, thus attenuating cardiocyte apoptosis. Other reaearch results showed that sodium formononetin-3'-sulfonate not only had favorable water, solubility but also had good lipid-lowering and liver-protection activities. |
|---|---|
| Related Catalog | |
| References |
[3]. Cardioprotective Effect of Sulfonated Formononetin on Acute Myocardial Infarction in Rats. |
| Molecular Formula | C16H11NaO7S |
|---|---|
| Molecular Weight | 370.31 |
| PSA | 122.42000 |
| LogP | 3.50170 |
|
~79%
949021-68-5 |
| Literature: Wang, Qiu-Ya; Zhang, Zun-Ting Journal of Chemical Crystallography, 2011 , vol. 41, # 10 p. 1467 - 1471 |
