MMBO
Modify Date: 2024-01-14 09:35:06
MMBO structure
|
Common Name | MMBO | ||
|---|---|---|---|---|
| CAS Number | 1005203-15-5 | Molecular Weight | 338.380 | |
| Density | 1.4±0.0 g/cm3 | Boiling Point | 579.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C18H14N2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 304.0±0.0 °C | |
Use of MMBOMMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively; inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD; suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models. |
| Name | 2-Methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole |
|---|---|
| Synonym | More Synonyms |
| Description | MMBO is a potent, highly selective, brain penetrant, orally active inhibitor of GSK-3 with IC50 of 37 and 53 nM for GSK-3α and GSK-3β, respectively; inhibits tau phosphorylation in primary neural cell culture and also in normal mouse brain, significantly decreases hippocampal tau phosphorylation at GSK-3 sites in transgenic mouse model of AD; suppresses tau pathology as assessed by AT8-immunoreactivity without affecting amyloid β pathology, significantly improves memory and cognitive deficits in AD models. |
|---|---|
| References | References 1. Onishi T, et al. J Neurochem. 2011 Dec;119(6):1330-40. View Related Products by Target GSK-3 |
| Density | 1.4±0.0 g/cm3 |
|---|---|
| Boiling Point | 579.0±0.0 °C at 760 mmHg |
| Molecular Formula | C18H14N2O3S |
| Molecular Weight | 338.380 |
| Flash Point | 304.0±0.0 °C |
| Exact Mass | 338.073000 |
| LogP | 2.27 |
| Vapour Pressure | 0.0±0.0 mmHg at 25°C |
| Index of Refraction | 1.713 |
| 1,3,4-Oxadiazole, 2-methyl-5-[3-[4-[(S)-(1S)-methylsulfinyl]phenyl]-5-benzofuranyl]- |
| 2-Methyl-5-(3-{4-[(S)-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: MMBO
- Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g ￥Inquiry/10ml
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: MMBO
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: MMBO
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g $150.0/10ml
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: s-1,3,4-Oxadiazole, 2-Methyl-5-[3-[4-(Methylsulfinyl)phenyl]-5-benzofuranyl]-
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
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