METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE

Modify Date: 2024-01-09 10:39:03

METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE structure	Common Name	METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
	CAS Number	10128-91-3	Molecular Weight	153.135
	Density	1.3±0.1 g/cm3	Boiling Point	287.3±20.0 °C at 760 mmHg
	Molecular Formula	C₇H₇NO₃	Melting Point	115-118ºC
	MSDS	N/A	Flash Point	127.5±21.8 °C

Name	Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
Synonym	More Synonyms

Density	1.3±0.1 g/cm3
Boiling Point	287.3±20.0 °C at 760 mmHg
Melting Point	115-118ºC
Molecular Formula	C₇H₇NO₃
Molecular Weight	153.135
Flash Point	127.5±21.8 °C
Exact Mass	153.042587
PSA	59.16000
LogP	0.29
Appearance of Characters	Solid \| Cream
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.552
Storage condition	Refrigerated.

Material Safety Data Sheet

Section1. Identiﬁcation of the substance
Methyl 2-hydroxynicotinate
Product Name:
Synonyms:Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate

Section2. Hazards identiﬁcation

Harmful by inhalation, in contact with skin, and if swallowed.
H315:Causes skin irritation
H319:Causes serious eye irritation
H335:May cause respiratory irritation
P261:Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340:IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405:Store locked up

Section3. Composition/information on ingredients.
Methyl 2-hydroxynicotinate
Ingredient name:
CAS number:10128-91-3

Section4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
ﬂushing of the eyes by separating the eyelids with ﬁngers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

Section5. Fire ﬁghting measures
In the event of a ﬁre involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualiﬁed
in the handling and use of potentially hazardous chemicals, who should take into account the ﬁre,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels, refrigerated.

Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section9. Physical and chemical properties
Not speciﬁed
Appearance:
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C7H7NO3
Molecular weight:153.1

Section10. Stability and reactivity
Conditions to avoid: Heat, ﬂames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

Section11. Toxicological information
No data.

Section12. Ecological information
No data.

Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section14. Transportation information
Non-harzardous for air and ground transportation.

Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

HS Code	2933399090

Methanol

CAS#:67-56-1

2-Hydroxy acid

CAS#:609-71-2

~82%

METHYL 6-OXO-1,...

CAS#:10128-91-3

Literature: SHIONOGI and CO., LTD. Patent: EP1357111 A1, 2003 ; Location in patent: Page/Page column 59-60 ;

2-Hydroxy acid

CAS#:609-71-2

~22%

METHYL 6-OXO-1,...

CAS#:10128-91-3

Literature: Abbott Laboratories Patent: US5250548 A1, 1993 ; US 5250548 A

2-Fluoronicotin...

CAS#:393-55-5

METHYL 6-OXO-1,...

CAS#:10128-91-3

Literature: WO2012/102580 A1, ; WO 2012/102580 A1

Methanol

CAS#:67-56-1

METHYL 6-OXO-1,...

CAS#:10128-91-3

Literature: Monatshefte fuer Chemie, , vol. 27, p. 364 Monatshefte fuer Chemie, , vol. 28, p. 441

Methanol

CAS#:67-56-1

2-hydroxynicoti...

CAS#:28369-76-8

METHYL 6-OXO-1,...

CAS#:10128-91-3

Literature: European Journal of Medicinal Chemistry, , vol. 61, p. 2 - 25

Precursor 4
CAS#:67-56-1 Methanol CAS#:609-71-2 2-Hydroxy acid CAS#:393-55-5 2-Fluoronicotin... CAS#:28369-76-8 2-hydroxynicoti...
DownStream 7
CAS#:78686-79-0 Methyl 5-bromo-... CAS#:78686-83-6 Methyl 2-chloro... CAS#:116387-40-7 Methyl 2-hydrox... CAS#:120034-05-1 Methyl 5-bromo-...
CAS#:153336-74-4 3-Pyridinecarbo... CAS#:67367-27-5 methyl 1-methyl... CAS#:868171-67-9 3-Pyridinecarbo...

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%