N-Demethylclarithromycin

Modify Date: 2026-07-17 22:44:56

N-Demethylclarithromycin Structure
N-Demethylclarithromycin structure
Common Name N-Demethylclarithromycin
CAS Number 101666-68-6 Molecular Weight 733.92700
Density 1.18±0.1 g/cm3 (20 ºC 760 Torr) Boiling Point N/A
Molecular Formula C37H67NO13 Melting Point 231-233 ºC
MSDS N/A Flash Point N/A

 Names

Name (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-6-[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.18±0.1 g/cm3 (20 ºC 760 Torr)
Melting Point 231-233 ºC
Molecular Formula C37H67NO13
Molecular Weight 733.92700
Exact Mass 733.46100
PSA 191.70000
LogP 2.48840
InChIKey CIJTVUQEURKBDL-RWJQBGPGSA-N
SMILES CCC1OC(=O)C(C)C(OC2CC(C)(OC)C(O)C(C)O2)C(C)C(OC2OC(C)CC(NC)C2O)C(C)(OC)CC(C)C(=O)C(C)C(O)C1(C)O

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

~92%

N-Demethylclarithromycin Structure

N-Demethylclari...

CAS#:101666-68-6

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Literature: RIB-X-PHARMACEUTICALS, INC. Patent: WO2008/106204 A1, 2008 ; Location in patent: Page/Page column 112 ;

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N-Demethylclarithromycin Structure

N-Demethylclari...

CAS#:101666-68-6

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Literature: US2009/76253 A1, ; Page/Page column 40 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 N-DemethylclarithromycinBioassay

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Name: Antibacterial activity against Moraxella catarrhalis ATCC 23246 after 24 hrs at 37 de...
Source: ChEMBL
Target: Moraxella catarrhalis
External Id: CHEMBL2025009
Name: Antibacterial activity against Haemophilus influenzae ATCC 49247 after 24 hrs at 37 d...
Source: ChEMBL
Target: Haemophilus influenzae
External Id: CHEMBL2025010
Name: Antibacterial activity against Streptococcus pneumoniae ATCC 149619 after 24 hrs at 3...
Source: ChEMBL
Target: Streptococcus pneumoniae
External Id: CHEMBL2025007
Name: Antibacterial activity against Streptococcus pyogenes ATCC 700294 after 24 hrs at 37 ...
Source: ChEMBL
Target: Streptococcus pyogenes
External Id: CHEMBL2025008
Name: Antibacterial activity against Staphylococcus aureus ATCC 13709 after 24 hrs at 37 de...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL2025006
Name: Antibacterial activity against macrolide-susceptible Staphylococcus aureus ATCC 29213
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL2064952
Name: Antibacterial activity against macrolide-resistant Staphylococcus aureus ATCC 33591 c...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL2064953
Total 7, Current Page 1 of 1
1

 Synonyms

N-Demethyl-6-O-methylerythromycin
3&3'-N-demethyl-6-O-methylerythromycin A
de(N-methyl) erythromycin A
N-Demethylclarithromycin
de(N-methyl)-6-O-methyl erythromycin
4'-desmethylclarithromycin
N-des-methylclarithromycin
Claricid Impurity 1
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